Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC007
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-27 15:28
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar 250mg 3x1/4; caps Madopar HBS125mg 1x1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 30, 'TN': 24, 'TP': 12, 'FP': 6}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 25, 'TN': 20, 'TP': 17, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 40, 'TN': 30, 'TP': 2, 'FP': 0}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.104
timePerCircleCoV 0.126145
timePerCircleSlope -0.0359263
meanError 2.57169
tremorFreq 5.76172
tremorRelPower 23.1271
tremorGyroAmpMean 0.0704216
tremorGyroAmpSlope 0.0429413
tremorGyroAmpCoV 0.628781
tremorCoordAmpMean 0.104665
tremorCoordAmpSlope 0.031929
tremorCoordAmpCoV 0.435814
tremorAccAmpMean 0.112113
tremorAccAmpSlope 0.00655105
tremorAccAmpCoV 0.202205
tremorPcRelVar 0.761169
tremorPcX 0.755273
tremorPcY -0.655411

Circle Segment 1

Duration 3.36 s, Accuracy Estimate 1.796 (lower is better)

Circle Segment 2

Duration 3.44 s, Accuracy Estimate 2.384 (lower is better)

Circle Segment 3

Duration 3.44 s, Accuracy Estimate 2.091 (lower is better)

Circle Segment 4

Duration 3.44 s, Accuracy Estimate 2.053 (lower is better)

Circle Segment 5

Duration 3.32 s, Accuracy Estimate 2.603 (lower is better)

Circle Segment 6

Duration 3.24 s, Accuracy Estimate 2.142 (lower is better)

Circle Segment 7

Duration 2.76 s, Accuracy Estimate 2.531 (lower is better)

Circle Segment 8

Duration 2.8 s, Accuracy Estimate 3.23 (lower is better)

Circle Segment 9

Duration 2.96 s, Accuracy Estimate 2.071 (lower is better)

Circle Segment 10

Duration 2.28 s, Accuracy Estimate 4.816 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 10.055
timePerSpiralCoV 0.0835524
timePerSpiralSlope 0.0181383
meanError 2.32586
tremorFreq 5.85938
tremorRelPower 19.4894
tremorGyroAmpMean 0.0802107
tremorGyroAmpSlope -0.0016643
tremorGyroAmpCoV 0.437575
tremorCoordAmpMean 0.0895179
tremorCoordAmpSlope -0.0024623
tremorCoordAmpCoV 0.314267
tremorAccAmpMean 0.0758573
tremorAccAmpSlope -0.00263394
tremorAccAmpCoV 0.267566
tremorPcRelVar 0.657353
tremorPcX -0.821787
tremorPcY -0.569794

Spiral Segment 1

Duration 8.68 s, Accuracy Estimate 2.44 (lower is better)

Spiral Segment 2

Duration 10.16 s, Accuracy Estimate 2.439 (lower is better)

Spiral Segment 3

Duration 9.84 s, Accuracy Estimate 2.052 (lower is better)

Spiral Segment 4

Duration 10.56 s, Accuracy Estimate 2.25 (lower is better)

Spiral Segment 5

Duration 10.8 s, Accuracy Estimate 1.921 (lower is better)

Spiral Segment 6

Duration 9.08 s, Accuracy Estimate 2.963 (lower is better)

Spiral Segment 7

Duration 10.16 s, Accuracy Estimate 2.21 (lower is better)

Spiral Segment 8

Duration 11.16 s, Accuracy Estimate 2.331 (lower is better)

Elel

eDurationMean 0.28625
eDurationStd 0.0529308
eDurationStdnorm 0.184911
eDurationMedian 0.27
eDurationQuartdelta 0.09
eDurationQuartdeltanorm 0.333333
eDurationKurt 1.87803
eDurationTrenddiff 0.0475
eDurationTrendratio 1.19
eWidthMean 1.37475
eWidthStd 0.44501
eWidthStdnorm 0.323703
eWidthMedian 1.3455
eWidthQuartdelta 0.702
eWidthQuartdeltanorm 0.521739
eWidthKurt 2.03107
eWidthTrenddiff -0.234
eWidthTrendratio 0.833333
eHeightMean 3.42956
eHeightStd 0.575911
eHeightStdnorm 0.167925
eHeightMedian 3.276
eHeightQuartdelta 0.9945
eHeightQuartdeltanorm 0.303571
eHeightKurt 1.98986
eHeightTrenddiff -0.468
eHeightTrendratio 0.870968
eAspectMean 0.398423
eAspectStd 0.103368
eAspectStdnorm 0.259442
eAspectMedian 0.39819
eAspectQuartdelta 0.107399
eAspectQuartdeltanorm 0.269718
eAspectKurt 2.19445
eAspectTrenddiff -0.0246072
eAspectTrendratio 0.940318
eSlantMean -0.183975
eSlantStd 0.143523
eSlantStdnorm -0.780119
eSlantMedian -0.133482
eSlantQuartdelta 0.195286
eSlantQuartdeltanorm -1.46302
eSlantKurt 2.43091
eSlantTrenddiff 0.073418
eRtopMean 0.549879
eRtopStd 0.235493
eRtopStdnorm 0.428264
eRtopMedian 0.516667
eRtopQuartdelta 0.363889
eRtopQuartdeltanorm 0.704301
eRtopKurt 2.16635
eRtopTrenddiff 0.122222
eRbotMean 1.04099
eRbotStd 0.299132
eRbotStdnorm 0.287354
eRbotMedian 1
eRbotQuartdelta 0.39881
eRbotQuartdeltanorm 0.39881
eRbotKurt 3.99123
eRbotTrenddiff 0.102381
eRrightMean 0.791481
eRrightStd 0.131416
eRrightStdnorm 0.166038
eRrightMedian 0.779412
eRrightQuartdelta 0.206623
eRrightQuartdeltanorm 0.265102
eRrightKurt 2.00384
eRrightTrenddiff -0.014385
eRleftMean 0.529485
eRleftStd 0.118831
eRleftStdnorm 0.224427
eRleftMedian 0.542262
eRleftQuartdelta 0.146276
eRleftQuartdeltanorm 0.269752
eRleftKurt 2.22344
eRleftTrenddiff -0.0895722
lDurationMean 0.466875
lDurationStd 0.0694333
lDurationStdnorm 0.148719
lDurationMedian 0.4525
lDurationQuartdelta 0.105
lDurationQuartdeltanorm 0.232044
lDurationKurt 1.99699
lDurationTrenddiff -0.0025
lDurationTrendratio 0.994505
lWidthMean 2.13525
lWidthStd 0.618316
lWidthStdnorm 0.289575
lWidthMedian 2.3985
lWidthQuartdelta 0.936
lWidthQuartdeltanorm 0.390244
lWidthKurt 2.04026
lWidthTrenddiff 0.8775
lWidthTrendratio 1.53571
lHeightMean 11.5538
lHeightStd 1.34386
lHeightStdnorm 0.116314
lHeightMedian 11.5245
lHeightQuartdelta 1.1115
lHeightQuartdeltanorm 0.0964467
lHeightKurt 3.28975
lHeightTrenddiff -0.9945
lHeightTrendratio 0.917073
lAspectMean 0.188708
lAspectStd 0.0644846
lAspectStdnorm 0.341717
lAspectMedian 0.217172
lAspectQuartdelta 0.104802
lAspectQuartdeltanorm 0.482575
lAspectKurt 1.59819
lAspectTrenddiff 0.0982657
lAspectTrendratio 1.78556
lSlantMean -0.0924208
lSlantStd 0.105194
lSlantStdnorm -1.1382
lSlantMedian -0.113812
lSlantQuartdelta 0.192261
lSlantQuartdeltanorm -1.68929
lSlantKurt 1.58084
lSlantTrenddiff -0.0847139
lRtopMean 0.842007
lRtopStd 0.0811579
lRtopStdnorm 0.0963863
lRtopMedian 0.823077
lRtopQuartdelta 0.108081
lRtopQuartdeltanorm 0.131313
lRtopKurt 2.711
lRtopTrenddiff -0.0117133
lRbotMean 1.4242
lRbotStd 0.624492
lRbotStdnorm 0.438486
lRbotMedian 1.41364
lRbotQuartdelta 0.890115
lRbotQuartdeltanorm 0.629664
lRbotKurt 2.23901
lRbotTrenddiff 0.00252525
lRrightMean 0.914769
lRrightStd 0.074876
lRrightStdnorm 0.0818524
lRrightMedian 0.931859
lRrightQuartdelta 0.120647
lRrightQuartdeltanorm 0.129469
lRrightKurt 1.80342
lRrightTrenddiff 0.0298986
lRleftMean 0.361757
lRleftStd 0.156318
lRleftStdnorm 0.432106
lRleftMedian 0.34738
lRleftQuartdelta 0.1894
lRleftQuartdeltanorm 0.545224
lRleftKurt 2.64618
lRleftTrenddiff -0.0368317

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

FITTS Short Modified

meanTouchScore 0.701507
sumTouchScores 9.82109
meanMovementTime 1.33385
numTouches 14
undershootPercentage 0
overshootPercentage 42.8571

FITTS Long Modified

meanTouchScore 0.127791
sumTouchScores 1.27791
meanMovementTime 1.86444
numTouches 10
undershootPercentage 10
overshootPercentage 60

ZigZag

numZigzags 5
timePerZigzagMean 20.224
timePerZigzagCoV 0.251205
timePerZigzagSlope -0.130934
meanError 2.71987
tremorFreq 7.12891
tremorRelPower 20.4072
tremorGyroAmpMean 0.0334655
tremorGyroAmpSlope 0.00275008
tremorGyroAmpCoV 0.532287
tremorCoordAmpMean 0.0457302
tremorCoordAmpSlope 0.00825231
tremorCoordAmpCoV 0.258232
tremorAccAmpMean 0.0322863
tremorAccAmpSlope 0.00914983
tremorAccAmpCoV 0.324974
tremorPcRelVar 0.731602
tremorPcX -0.0907312
tremorPcY -0.995875

ZigZag Segment 1

Duration 28.36 s, Accuracy Estimate 2.301 (lower is better)

ZigZag Segment 2

Duration 21.68 s, Accuracy Estimate 2.873 (lower is better)

ZigZag Segment 3

Duration 15.8 s, Accuracy Estimate 3.047 (lower is better)

ZigZag Segment 4

Duration 18.64 s, Accuracy Estimate 2.482 (lower is better)

ZigZag Segment 5

Duration 16.64 s, Accuracy Estimate 2.896 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 19.896
timePerZigzagCoV 0.255449
timePerZigzagSlope -0.143747
zigzagHeightMean 70.1919
zigzagHeightCoV 0.0451875
zigzagHeightSlope -0.0220714
meanError 0.0535401
tremorFreq 5.76172
tremorRelPower 21.4578
tremorGyroAmpMean 0.0370299
tremorGyroAmpSlope 0.00396924
tremorGyroAmpCoV 0.46464
tremorCoordAmpMean 0.158793
tremorCoordAmpSlope -0.0172835
tremorCoordAmpCoV 2.0849
tremorAccAmpMean 0.102923
tremorAccAmpSlope 0.00176236
tremorAccAmpCoV 0.192384
tremorPcRelVar 0.89651
tremorPcX -0.276719
tremorPcY 0.960951

ZigZag Offset Segment 1

Duration 24.2 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 2

Duration 22.08 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 23.96 s, Accuracy Estimate 0.027 (lower is better)

ZigZag Offset Segment 4

Duration 16.6 s, Accuracy Estimate 0.052 (lower is better)

ZigZag Offset Segment 5

Duration 12.64 s, Accuracy Estimate 0.107 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.78}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.03755710808125845}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.7360145230000155}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}